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Medical Abortion with Methotrexate and Misoprostol

Some abortion clinics offer non-surgical Medical Abortion using Methotrexate and Misoprostol in the early stages of pregnancy (usually before 7-8 weeks LMP).

The two drugs are not approved specifically for this purpose by the FDA, but have been used successfully by many doctors.

Methotrexate and Misoprostol to Terminate Early Pregnancy [article]
by Richard U. Hausknecht, MD
N Engl J Med 1995; 333:537-540August 31, 1995DOI: 10.1056/NEJM199508313330901

How a Medical Abortion with Methotrexate and Misoprostol Works

The use of Methotrexate and Misoprostol is a two-step method.

  1. At your doctor's office you will be given Methotrexate tablets to be taken by mouth or by injection. The Methotrexate interferes with the growth of the placenta, which allows it to separate from the endometrium.
  2. At home, tablets of Misoprostol are to be taken by mouth, usually 5 to 7 days later causing uterine contractions so that your body passes the uterine contents. The pregnancy usually ends at home within a day or two.

A medical abortion usually requires at least two visits to your doctor. The 2nd visit is a follow-up appointment and is usually scheduled about 2 weeks after the first visit to make sure the abortion is complete and no complications are present.

NOTE: If, a medical abortion is unsuccessful, a surgical abortion must be done to complete the process.


Abortion clinics offering non-surgical Medical Abortion using Methotrexate and Misoprostol listed below:

Arizona Abortion Clinics

Arkansas Abortion Clinics

California Abortion Clinics

Florida Abortion Clinics

Maryland Abortion Clinics

Minnesota Abortion Clinics

New Hampshire Abortion Clinics

New Jersey Abortion Clinics